Customers regularly ask us: How should I store Uthever® NMN? How stable is it at room temperature? Do I need to store it in the refrigerator?
In this article we would like to address precisely these questions and at the same time show you that Uthever® NMN is one of the most stable products on the market.
Stability test - To test the stability, the following conditions were assumed:
1. packed NMN in double-walled polyethylene bags.
2. storage at 40℃
3. storage at 75% humidity
So we are talking here about a relatively high, summer temperature in Germany and a typical humidity in indoor air.
Three different batches of Uthever® NMN were tested for purity and moisture under these conditions after one month, after two months, after three months and after six months.
The results are staggered as follows:
As you can see, even after six months of storage under relatively extreme conditions, Uthever® NMN has lost on average just 0.1% of its purity.
Storage at room temperature is therefore absolutely safe.
Sources used
Superman and the Vitamin B3 Family
Denu, J. M. (2007). Vitamins and aging: pathways to NAD+ synthesis. Cell, 129(3), 453-454.
OECD, P. G. D. (2013). What future for health spending? OECD Economics Department Policy Notes, No. 19.
Uddin, G. M., Yongson, N., Sinclair, D., & Morris, M. (2015). Effects of High Fat Diet Induced Obesity on Mitochondrial Biogenesis and Function-Impact of Exercise or Nicotinamide Mononucleotide (NMN). The FASEB Journal, 29(1_supplement), 777-8.
Zhang, H. et al. (2016). NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 352(6292), 1436-1443.
Hwang, E. S., & Hwang, S. Y. (2018). Cellular NAD⁺ level: a key determinant of mitochondrial quality and health. Annals of Geriatric Medicine and Research, 21(4), 149-157.
Kirkland, J. B., & Meyer-Ficca, M. L. (2018). Niacin. In Advances in food and nutrition research (Vol. 83, pp. 83-149). Academic Press.
Irie, J. et al. (2020). Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Endocrine journal, 67(2), 153-160.
NR vs. NMN - blue pill vs. red pill
Yoshino, J., Mills, K. F., Yoon, M. J., & Imai, S. I. (2011). Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet-and age-induced diabetes in mice. Cell metabolism, 14(4), 528-536.
Cantó, C. et al. (2012). The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell metabolism, 15(6), 838-847.
Chi, Y., & Sauve, A. A. (2013). Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection. Current Opinion in Clinical Nutrition & Metabolic Care, 16(6), 657-661.
Mills, K. F. et al. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell metabolism, 24(6), 795-806.
Trammell, S. A. et al. (2016). Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature communications, 7(1), 1-14.
Wang, X., Hu, X., Yang, Y., Takata, T., & Sakurai, T. (2016). Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death. Brain research, 1643, 1-9.
Zhang, H. et al. (2016). NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 352(6292), 1436-1443.
Airhart, S. E. et al. (2017). An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PloS one, 12(12).
Hwang, E. S., & Hwang, S. Y. (2018). Cellular NAD⁺ level: a key determinant of mitochondrial quality and health. Annals of Geriatric Medicine and Research, 21(4), 149-157.
Grozio, A. et al. (2019). Slc12a8 is a nicotinamide mononucleotide transporter. Nature metabolism, 1(1), 47-57.
Tarantini, S. et al. (2019). Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox biology, 24, 101192.
Irie, J. et al. (2020). Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Endocrine journal, 67(2), 153-160.
Podcast David Sinclair
Is ageing a disease?
Podcast UIBK
World Report on Ageing and Health (WHO)
Specht, J., Egloff, B., & Schmukle, S. C. (2011). Stability and change of personality across the life course: The impact of age and major life events on mean-level and rank-order stability of the Big Five. Journal of Personality and Social Psychology, 101(4), 862-882.
Gerstorf, D., Hoppmann, C. A., Löckenhoff, C. E., Infurna, F. J., Schupp, J., Wagner, G. G., & Ram, N. (2016). Terminal decline in well-being: The role of social orientation. Psychology and Aging, 31(2), 149.
Kruse, A. (2017). Life phase of old age: vulnerability and maturity. Springer-Verlag.
https://www.pschyrembel.de/Krankheit/K0C8J
Ageing is what you make of it
Robine, J. M., Allard, M., Herrmann, F. R., & Jeune, B. (2019). The real facts supporting Jeanne Calment as the oldest ever human. The Journals of Gerontology: Series A, 74(Supplement_1), S13-S20.
https://www.smithsonianmag.com/smart-news/oldest-person-world-turns-117-180973930/
https://www.7jahrelaenger.de/7jl/magazin/jedes-dritte-maedchen-wird-100-jahre-alt-55020
https://sz-magazin.sueddeutsche.de/gesundheit/das-ist-ja-der-gipfel-79492
Antioxidants
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007). Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. Jama, 297(8), 842-857.
Lehman-McKeeman, L. D. (2013). Biochemical and Molecular Basis of Toxicity. In Haschek and Rousseaux's Handbook of Toxicologic Pathology (pp. 15-38). Academic Press.
Tsopmo, A., Awah, F. M., & Kuete, V. (2013). Lignans and stilbenes from African medicinal plants. In Medicinal plant research in Africa (pp. 435-478). Elsevier.
Bjelakovic, G., Nikolova, D., & Gluud, C. (2014). Antioxidant supplements and mortality. Current Opinion in Clinical Nutrition & Metabolic Care, 17(1), 40-44.
Kubo, E., Chhunchha, B., Singh, P., Sasaki, H., & Singh, D. P. (2017). Sulforaphane reactivates cellular antioxidant defence by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress. Scientific reports, 7(1), 1-17.
Zhou, J., Ci, X., Ma, X., Yu, Q., Cui, Y., Zhen, Y., & Li, S. (2019). Pterostilbene activates the Nrf2-dependent antioxidant response to ameliorate arsenic-induced intracellular damage and apoptosis in human keratinocytes. Frontiers in pharmacology, 10.
Longevity paths
Salminen, A., Huuskonen, J., Ojala, J., Kauppinen, A., Kaarniranta, K., & Suuronen, T. (2008). Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging. Ageing research reviews, 7(2), 83-105.
Zineldeen, D. H., Uranishi, H., & Okamoto, T. (2010). NF-kappa B signature on the aging wall. Current drug metabolism, 11(3), 266-275.
Salminen, A., & Kaarniranta, K. (2012). AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing research reviews, 11(2), 230-241.
Lamming, D. W., Ye, L., Sabatini, D. M., & Baur, J. A. (2013). Rapalogs and mTOR inhibitors as anti-aging therapeutics. The Journal of clinical investigation, 123(3), 980-989.
Burkewitz, K., Zhang, Y., & Mair, W. B. (2014). AMPK at the nexus of energetics and aging. Cell metabolism, 20(1), 10-25.
Cartwright, T., Perkins, N. D., & Wilson, C. L. (2016). NFKB1: a suppressor of inflammation, ageing and cancer. The FEBS journal, 283(10), 1812-1822.
Kida, Y., & Goligorsky, M. S. (2016). Sirtuins, cell senescence, and vascular aging. Canadian Journal of Cardiology, 32(5), 634-641.
Wątroba, M., Dudek, I., Skoda, M., Stangret, A., Rzodkiewicz, P., & Szukiewicz, D. (2017). Sirtuins, epigenetics and longevity. Ageing research reviews, 40, 11-19.
Weichhart, T. (2018). mTOR as regulator of lifespan, aging, and cellular senescence: a mini-review. Gerontology, 64(2), 127-134.
Stallone, G., Infante, B., Prisciandaro, C., & Grandaliano, G. (2019). mtor and aging: An old fashioned dress. International journal of molecular sciences, 20(11), 2774.
Fasting - perspective for a long life
Longo, V. D., & Mattson, M. P.. (2014). Fasting: molecular mechanisms and clinical applications. Cell metabolism, 19(2), 181-192.
Mitchell, S. J., Bernier, M., Mattison, J. A., Aon, M. A., Kaiser, T. A., Anson, R. M., ... & de Cabo, R. (2019). Daily fasting improves health and survival in male mice independent of diet composition and calories. Cell metabolism, 29(1), 221-228.
de Cabo, R., Carmona-Gutierrez, D., Bernier, M., Hall, M. N., & Madeo, F. (2014). The search for antiaging interventions: from elixirs to fasting regimens. Cell, 157(7), 1515-1526.
Longo, V. D., & Panda, S. (2016). Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan. Cell metabolism, 23(6), 1048-1059.
Velingkaar, N., Mezhnina, V., Poe, A., Makwana, K., Tulsian, R., & Kondratov, R. V. (2020). Reduced caloric intake and periodic fasting independently contribute to metabolic effects of caloric restriction. Aging Cell, 19(4), e13138.
Balasubramanian, P., Howell, P. R., & Anderson, R. M. (2017). Aging and caloric restriction research: a biological perspective with translational potential. EBioMedicine, 21, 37-44.
