AMPK

What is AMPK?

AMPK or AMP-activated protein kinase is an enzyme that plays a central role in cellular energy homeostasis. It acts as an energy sensor at the cellular level and is activated when cells experience a lack of energy, for example through physical activity, fasting or stress. Once activated, AMPK sets processes in motion that lead to the restoration of energy balance by reducing energy consumption and increasing energy production.

What is the function of AMPK in the human body?

Its functions in the human body are diverse and vital. It regulates a number of metabolic pathways that are important for maintaining energy balance, promoting glucose uptake into the muscles, increasing fat oxidation and inhibiting lipid synthesis. As a result, it plays a crucial role in regulating body weight, insulin resistance and overall metabolic health. It is also one of the four longevity pathways (together with sirtuins, mTOR and NF-kB).

How can AMPK be activated?

Activation can take place in various ways, including through exercise, fasting and certain foods or supplements. Exercise is one of the most effective ways to activate AMPK, as it increases the cells' energy requirements and thus stimulates the enzyme. Fasting or calorie-restricted diets can also activate AMPK by lowering cellular energy levels and encouraging the body to draw on stored energy sources.

Which foods contain AMPK activators?

Certain foods and ingredients can promote the activation of AMPK. These include, among others:

• Curcurmin, the active ingredient in turmeric, has been shown to activate AMPK in various tissues.
• Resveratrol, a polyphenol found in red grapes, berries and nuts, is known for its ability to stimulate the enzyme.
• Green tea, in particular the ingredient epigallocatechin gallate (EGCG), promotes activation and supports fat burning.

Here you can find a table of foods that can activate AMPK:

These nutrients and foods, together with a balanced diet and regular exercise, can help to activate this important enzyme and thus support metabolic health.

Did you know?

The activation of AMPK is one of the promising ways in which age researchers hope to stop diseases and ageing. Dozens of studies have been published in recent years. All the combined knowledge and experience of experts has gone into the development of ONE, our innovative approach to making longevity as accessible and simple as possible.

What role does AMPK play in longevity?

The role of AMPK in longevity is the subject of intense research. Studies suggest that activation of this pathway can help extend lifespan by improving metabolic efficiency, reducing inflammation and promoting cellular clearance(autophagy). These processes are crucial for slowing down age-related degeneration and disease. Consequently, the targeted activation of AMPK could be a promising approach to promote health and longevity.

Conclusion AMPK

In summary, AMP-activated protein kinase is a key enzyme that plays an essential role in the body's energy balance. Through its multiple functions in metabolism and its potential to extend lifespan, AMPK offers exciting opportunities for health and well-being. Activating AMPK through exercise, targeted nutrition and certain foods is an effective strategy to harness the multiple benefits of this enzyme.