The ONE - MoleQlar's daily longevity complex - was developed in collaboration with many experts. The formulation contains everything that makes MoleQlar special: Longevity innovation, the latest science and outstanding quality. One sachet a day provides you with these 13 high-quality Longevity molecules:
Calcium alphaketoglutarate, trans-resveratrol, luteolin, quercetin, glycine, theanine, hyaluronic acid, glucosamine, inositol, creatine, magnesium taurate, L-citrulline malate and vitamin C
Why exactly these 13? There are now many health drinks with overwhelming compositions. True to the motto the more ingredients the better, the individual molecules are usually contained in very low concentrations that have not been tested for their effects in studies. With MoleQlar ONE, the approach was different. We examined a large number of molecules and evaluated them in terms of their potential to promote longevity. It was particularly important to us that the dosages used were based on scientific evidence.
What is ageing?
Ageing is enormously complex. All the signs of ageing that we see and feel are just the end point of molecular processes that often no longer function properly over years and decades. If we feel less efficient over time and are exhausted more quickly, we have probably been suffering from mitochondrial dysfunction for some time. If we forget things more quickly or if age pigments become visible in our skin, then we have lost proteostasis. None of this happens overnight - it develops gradually at a molecular level and at different rates in different people.
In addition to the two mentioned above, there are ten other signs of ageing - twelve in total. A team led by scientist Carlos Lopez Otin has discovered and defined these hallmarks. These "hallmarks of ageing" underlie all age-related diseases and changes. The researchers hypothesize that if we could reverse these hallmarks, we would age more slowly or not at all. However, research is not yet far enough along for the latter.
To help you better understand which processes accelerate ageing and how the various molecules of the MoleQlar ONE complex affect your body, we will give you a brief overview of each:
Calcium alphaketoglutarate (AKG)
Alphaketoglutarate (AKG) is an unwieldy name for an important enzyme in the citrate cycle. You may remember this metabolic pathway from your biology lessons. It takes place in our cellular power plants (mitochondria) and helps you to produce enough energy in the form of ATP every day. Between the ages of 40 and 80, however, the body's stores of AKG decrease by a factor of 10.(R) The consequence of this is a stuttering energy supply. This is exactly where CaAKG comes in, by boosting your energy metabolism. However, there is no AKG in our diet, which is why we are dependent on supplements, for example. The combination with calcium ensures that AKG is absorbed more efficiently in the intestine.
AKG study situation:
In human studies, AKG was able to support muscle and bone formation(R, R). In animal studies, some of the organisms studied lived up to 50% longer.(R) Larger studies on humans are still ongoing, but initial data has shown a reduction in biological age by several years.(R) In addition to generally supporting your energy metabolism, AKG is also particularly valuable for your intestinal cells, whereby the molecule indirectly contributes to an improved microbiome. By converting pro-collagen into collagen, alpha ketoglutarate can also support your body in wound healing.(R)
CaAKG plays a role here: energy metabolism, bone metabolism, immune system, microbiome
Hallmarks of Aging: CaAKG affects the following Hallmarks of Aging:
- Mitochondrial dysfunction
- Epigenetic changes
- Stem cell exhaustion
- Inflammaging - inflammatory aging
- Microbiome dysbiosis
Trans-Resveratrol
Perhaps you've heard of the French paradox? Despite eating lots of meat, cheese and wine, the French live longer on average. Longevity researchers led by Professor David Sinclair believe they have found the key to this riddle: Resveratrol. This polyphenol, which is mainly found in the skin of red grapes, seems to be responsible for the French paradox. For plants, resveratrol is a natural defense against harsh environmental conditions and pathogens. In humans, resveratrol is a potent activator of various longevity pathways at the molecular level. The trans-resveratrol form has been shown in studies to be more stable and more bioavailable.
Resveratrol study situation:
The longevity pathways influenced by resveratrol include sirtuins and AMPK.(R, R) Sirtuins in particular, also known as longevity genes, are considered one of the most promising approaches in longevity research.(R)
Furthermore, resveratrol leads to improved cell resistance to oxidative stress by activating the transcription factor Nrf2.(R) The grape polyphenol therefore combines a whole range of desirable effects. In several studies, resveratrol has extended the life of fruit flies and mice. The researchers found that the activity of the sirtuins is dependent on NAD, among other factors.(R,R)
Trans-resveratrol plays a role here: energy metabolism, immune system, microbiome, epigenetics
Hallmarks of Aging:
- Mitochondrial dysfunction
- Genomic instability
- Epigenetic changes
- Telomere shortening
- Deregulated nutrient measurement
- Prevented macroautophagy
- Inflammaging - inflammatory aging
- Microbiome dysbiosis
Luteolin
The molecule belongs to the flavonoid family and occurs naturally in olive oil, rosemary and thyme.
Luteolin study situation:
Similar to resveratrol, it can activate the longevity genes, known as sirtuins.(R) According to studies, luteolin can also help the body to better eliminate defective cells. The molecule does this by inhibiting the nuclear factor kappa-B(NF-kB).(R) NF-kB is one of the signaling pathways that become unbalanced with age. Excessive NF-kB levels lead to so-called inflammaging, an excessive inflammatory reaction in old age that takes place throughout the body.
Another positive effect of luteolin: the flavonoid supports the recycling of NAD, one of your most important enzymes in energy metabolism. Luteolin stimulates the key enzyme NAMPT, which converts NAM into NMN. This is the speed-determining step in the so-called salvage pathway.(R)
Luteolin plays a role here: immune system, epigenetics
Hallmarks of Aging:
- Inflammaging - inflammatory aging
- Cellular senescence
- Altered intercellular communication
- Epigenetic change
Quercetin
Quercetin is found in the skin of apples and makes them taste bitter. Professor James L. Kirkland of the renowned Mayo Clinic was one of the first to discover the potential of quercetin.(R)
Hallmarks of Aging:
- Inflammaging - inflammatory aging
- Cellular senescence
- Altered intercellular communication
- Epigenetic change
- Loss of proteostasis
- Mitochondrial dysfunction
- Dysregulated nutrient measurement & fasting
- Prevented macroautophagy
- Microbiome dysbiosis
L-glycine
Glycine is a non-essential amino acid that is involved in countless metabolic processes in your body. It is a component of collagen, a structural protein found in the skin, bones and tendons. Glycine is also part of the structural formula of glutathione. This molecule is one of the most important for the elimination of free radicals. As we age, glutathione levels decrease, which can lead to more cell damage.(R)
Glycine study situation:
In animal experiments, glycine was able to prolong the life of both mice and worms.(R,R) In clinical studies, it has already been shown that glycine intake was able to reduce long-term glucose (HbA1c) in diabetics and that blood pressure in hypertensive patients decreased after three months of intake.(R,R)
In the form of GlyNAC it has also been shown in humans that glycine can influence various hallmarks of aging in humans, including mitochondrial dysfunction and genomic instability.(R) Further areas of application are currently being researched, but glycine has already been given the name "geroprotector". Loosely translated, this means something like: Age protector.
L-glycine plays a role here: immune system, microbiome, epigenetics, energy metabolism, skin and bone metabolism
Hallmarks of Aging:
- Inflammaging - inflammatory aging
- Epigenetic change
- Loss of proteostasis
- Mitochondrial dysfunction
- Dysregulated nutrient measurement & fasting
- Prevented macroautophagy
- Microbiome dysbiosis
- Stem cell exhaustion
Theanin
The health-promoting properties of green tea have long been known in Asian culture and research is slowly uncovering the molecules behind them. On the one hand, there is the complicated-sounding epigallocatechin gallate (EGCG), which supports your NAD metabolism. The hot drink also supports your metabolic health by regulating blood sugar levels.(R,R)
Theanine study situation:
The amino acid theanine in green tea increases your concentration and if you have drunk too much coffee, theanine can compensate for this. It has long been known that tea has a calming effect on the body and mind. This effect seems to come mainly from theanine.(R)
But these are by no means all the benefits of this molecule. In this randomized study(R), regular intake of theanine led to a reduction in colds.
Theanine plays a role here: immune system, energy metabolism
Hallmarks of Aging:
- Inflammaging - inflammatory aging
- Altered intercellular communication
- Epigenetic changes
- Dysregulated nutrient measurement & fasting
- Microbiome dysbiosis
Hyaluronic acid
Hyaluron is known as a "wrinkle filler" in the cosmetics industry. Thanks to its water-binding properties, hyaluron supports our largest organ, the skin, against premature ageing. As we age, our hyaluronic acid content decreases steadily. A 75-year-old person only has about a quarter of the hyaluronic acid content in their skin as a 19-year-old person.(R)
Hyaluron study situation:
Hyaluron as a supplement was tested in this randomized study, among others.(R). The result: in 60 test subjects,the depth of wrinkles was reduced after just 28 days of regular use of hyaluronic acidand the skin was on average 10.6% better hydrated.
In addition to the skin, hyaluronic acid is also found in cartilage. Around 5g of hyaluronic acid is synthesized and broken down here every day. It is therefore no wonder that it is essential for our joints as a "lubricant". In a Japanese study, 60 test subjects with knee osteoarthritis were treated with hyaluronic acid for a whole year and their symptoms improved as a result of the treatment.(R)
Due to its anti-inflammatory properties and its ubiquitous occurrence in the body, hyaluronic acid is also being researched in the treatment of other diseases.(R)
Hyaluronic acid plays a role here: immune system, skin, bone and cartilage metabolism
Hallmarks of Aging:
- Inflammaging - inflammatory aging
- Altered intercellular communication
- Stem cell exhaustion
- Altered macroautophagy
Glucosamine
Our body needs glucosamine when it wants to combine carbohydrates with fats or proteins to produce new molecules. This molecule is particularly common in joints and connective tissue, which is why it is also taken in practice for joint pain. In the form of glucosamine sulphate, the body can demonstrably absorb glucosamine. Scientists have found increased levels of glucosamine both in the blood and in the synovial fluid after taking glucosamine sulphate.(R,R)
Glucosamine study situation:
In two randomized studies(R,R), the intake of glucosaminosulfate slowed down cartilage degradation and alleviated symptoms in people with osteoarthritis of the knee. Glucosamine appears to reduce inflammatory signaling proteins such as interleukin 1.(R)
New research also shows a longevity effect of glucosamine, in which autophagy, the cell's own recycling system, is increased. Furthermore, glucosaminosulphate has an anti-inflammatory effect by down-regulating the nuclear factor kappa-B(NF-kB). The researchers also suspect that this is one of the reasons for the positive effect of glucosaminosulphate on longevity.(R,R)
Glucosamine sulphate plays a role here: immune system, sugar and cartilage metabolism
Hallmarks of Aging:
- Inflammaging - inflammatory aging
- Altered intercellular communication
- Prevented macroautophagy
- Mitochondrial dysfunction
- Loss of proteostasis
- Genomic instability
Inositol
This vitamin-like molecule supports your sugar and fat metabolism. As an endogenous substance, inositol is mainly found in cell membranes, for example in the liver, kidneys and brain. Inositol is either produced by the body itself or absorbed through plant-based foods such as grapefruit juice.(R,R)
Inositol study situation:
Several studies on women with polycystic ovary syndrome (PCO) and inositol were summarized in a large meta-analysis. Taking inositol not only improved their insulin sensitivity, the researchers also found improved fertility.(R)
Inositol substitution can also be beneficial for other diseases, such as non-alcoholic fatty liver disease (NAFLD).(R) In patients with hypothyroidism, a combined intake of selenium and inositol was able to lower the hormone TSH and reduce the antibodies against the thyroid gland. This alleviated the symptoms of hypothyroidism.(R)
With this broad range of applications and the many clinical research projects, inositol is a promising molecule for the future.
Inositol plays a role here: immune system, sugar and fat metabolism and hormone balance
Hallmarks of Aging:
- Inflammaging - inflammatory aging
- Altered intercellular communication
- Mitochondrial dysfunction
- Loss of proteostasis
Creatine Monohydrate
Creatine is an essential. With the help of this molecule, the muscle's own ATP reserves can be increased, which is noticeable as increased strength. As we age, our body's own creatine production decreases, which is why it makes sense for non-athletes to take creatine too.(R) From the age of 50, muscle mass decreases by 1-2% per year, muscle strength even by 1-5%.(R,R,R) We can compensate for this for a long time, but at some point the muscles become so weak that even previously simple things, such as climbing stairs, become more difficult. For this reason, strength training in combination with creatine is an effective approach to maintaining muscle strength in old age.
Creatine study situation:
In addition to its strength-enhancing effect, creatine dampens pro-inflammatory processes in the body and thus supports your immune system.(R) In addition, creatine leads to improved cognitive performance and in animal studies offered protection against neurodegenerative diseases by promoting the elimination of lipofuscin in the brain, also known as "age pigment".(R)
Creatine also appears to have a positive effect on depression. In a randomized, double-blind study (the highest standard of science), creatine supported the absorption and effect of SSRIs, a group of antidepressants.(R)
Creatine plays a role here: immune system, muscle and bone metabolism, cognitive performance
Hallmarks of Aging:
- Inflammaging - inflammatory aging
- Altered intercellular communication
- Mitochondrial dysfunction
- Loss of proteostasis
Magnesium taurate
Magnesium is the eighth most common element in the earth's crust and occurs in various chemically bound forms. In our body, magnesium is involved as a co-factor in more than 300 enzymes that have a wide variety of functions in the body. From protein biosynthesis, muscle and nerve signals to the regulation of blood sugar and blood pressure.(R) According to the National Consumption Study II of the Federal Ministry of Food, Agriculture and Consumer Protection, the majority of people do not consume enough magnesium.(R)
Magnesium study situation:
A magnesium deficiency is associated with some important "diseases of old age", such as arteriosclerosis, increased blood lipid levels, Alzheimer's disease and type 2 diabetes mellitus.(R) The functions of magnesium in the body are manifold, as shown by the number of enzymes in which magnesium is involved. It also helps to stabilize the genome, thereby reducing DNA damage.(R,R)
The organic combination of the amino acid taurine with magnesium also ensures improved bioavailability and taurine also acts as a mediator for healthy mitochondria.(R,R) Magnesium reduces tiredness and fatigue, promotes your energy metabolism and calms the nerves.
Magnesium taurate plays a role here: immune system, muscle metabolism, cognitive performance, sleep, energy metabolism, cardiovascular health, insulin sensitivity
Hallmarks of Aging:
- Inflammaging - inflammatory aging
- Mitochondrial dysfunction
- Genomic instability
- Telemora abrasion
- Deregulated nutrient measurement
Citrulline malate
The amino acid L-citrulline occurs naturally in watermelon and is involved in the urea cycle in the liver and kidneys, for example. L-citrulline leads to improved nitric oxide (NO) production in the body. To achieve this effect, however, you would have to consume at least 1-1.5 kg of watermelon per day!(R)
Malate is the salt of malic acid and is found in the body in the citrate cycle, among other places. Just like alphaketoglutarate.
Citrulline study situation:
Nitric oxide (NO) is needed by our blood vessels to make them dilate (vasodilation). As we age, our cardiovascular health tends to deteriorate, NO levels fall and blood pressure rises.(R) For this reason, it can be beneficial if the body's own NO production is increased again. In principle, L-arginine and L-citrulline are suitable for this, as both are involved in nitrogen metabolism. Although L-arginine is the direct precursor of NO, supplementation of L-arginine is not effective and leads to more side effects. L-citrulline in combination with malate is better absorbed and is more effective in increasing NO synthesis.(R,R)
The increased NO production also benefits your muscles. They can generate more power due to the increased blood flow.(R)
Malate has been shown to improve lifespan and mitochondrial function in animal studies.(R,R). As part of the citrate cycle, malate is involved in the production of energy in the form of ATP. Supplementation in mice showed increased energy production.(R)
L-citrulline malate plays a role here: energy metabolism, cardiovascular system
Hallmarks of Aging:
- Mitochondrial dysfunction
- Dysregulated nutrient measurement & fasting
Vitamin C (ascorbic acid)
Our body cannot produce vitamin C itself, which is why we are dependent on our food. If we do not do this sufficiently, we can become seriously ill. In the past, sailors in particular often had a vitamin C deficiency due to a lack of fresh fruit, which manifested itself in the disease scurvy.(R,R)
Vitamin C has a variety of roles in the body. It contributes to normal immune function, supports the energy balance, helps with muscle recovery, is involved in collagen formation for skin and bones and protects you from infections.(R,R,R)
Vitamin C study situation:
Vitamin C as a single molecule is not associated with increased longevity - at least there are no studies on this (yet). However, it does have some synergistic effects, particularly with alphaketoglutarate. In addition, vitamin C is being researched as an adjunct in the treatment of cancer(R) and it helps to shorten the duration of the common cold.(R)
Vitamin C plays a role here: energy metabolism, immune system
Hallmarks of Aging:
- Genomic instability
- Telomere shortening
- Loss of protostasis
- Cellular senescence
- Mitochondrial dysfunction
- Epigenetic change
- Altered intercellular communication
