What is regeNAD (NAD Regenerating Complex)?

NAD(nicotinamide adenine dinucleotide) is one of the most popular molecules in longevity research. This is no coincidence, as it has been widely demonstrated that our NAD levels drop sharply with age. At the same time, studies show that increasing NAD levels is associated with numerous positive effects on various aspects of our health. For longevity researchers such as David Sinclair and Mark Hyman, NAD is the answer to key questions about aging. But how can we maintain our NAD levels and what role can MoleQlar's regeNAD play?

On the one hand, precursor molecules can be supplemented and on the other hand, the degradation can be slowed down. A third possibility is to support the NAD-producing enzymes. regeNAD by MoleQlar combines all three possibilities. The composition of the NAD Regenerating Complex is based on the latest scientific findings and well-researched molecular pathways.

NAD - why you want to keep your level up as you age

Higher levels of NAD have produced impressive results in animal studies. The animals studied not only lived significantly longer on average (between 10 and 20%, depending on the study), but were also significantly fitter. Their insulin sensitivity and memory performance were significantly better than in the control groups. The first studies in humans are also already showing good results and there are many more clinical studies underway. To give you a better understanding of the biochemical background, we will briefly show you the most important points as an overview.

NAD metabolism - a brief overview

NAD metabolism is extremely complex and many molecules and enzymes play a role. Here you will find a brief summary of the most important points:

• NAD is constantly built up and broken down in our body
• There are three wayshow our body can produce NAD:
  • Price handler path (Niacin)
  • Recycling path (NMN, NR, Nam)
  • de novo pathway (tryptophan)
• The rate-determining step ("bottleneck") for the production of NAD is facilitated by an enzyme called NAMPT - NMNAT is also very important
• As we age, the amount of NAD in our bodies decreases.
• The reasons are as follows:
  • Production decreases (fewer precursors, fewer enzymes)
  • The degradation or consumption increases. This occurs through various enzymes that become active with age. One of these is called CD38.
• Higher inflammation levels increase CD38 activity and thereby decrease NAD
• Researchers have found in numerous animal studies, as well as in human trials, that high levels of NAD were associated with improved health in old age.

For more background knowledge, you can always read our detailedarticle on NAD metabolism.

Boosting NAD - why preamps are not enough

High NAD levels seem to be a promising way to more vitality in old age. The first, logical step would be to resort to the ready-made molecule. This quickly proved not to be very effective. NAD (whether intravenous or oral) is "too big" and cannot be absorbed directly by our cells.

Let's take another look at NAD metabolism. Nicotinamide adenine dinucleotide is known to be produced in three different pathways. All three decline with age, so let's look at how we can strengthen each pathway.

Via the "de novo pathway", our body can produce new NAD on the basis of various precursors. The only question that remains is, which precursor? This question has not yet been fully answered. There are some, human studies on NR (Nicotinamide Riboside) as a supplement. Here, however, the results are mixed, as not all people experienced an increase in NAD, but some increased degradation products. Another possibility is to provide more "material" for synthesis. Our body takes as a basis for the synthesis of new NAD the amino acid L-tryptophan. If we increase the supply of this amino acid, we can support the "de novo pathway".

Nicotinamide and nicotinic acid are two very similar molecules. They differ only in one chemical group. Nicotinic acid, also abbreviated NA, contains a carboxyl group (COOH), while nicotinamide has a nitrogen-containing amide group. Both are derivatives of vitamin B3, also called niacin. Although very similar in structure, the two molecules are metabolized somewhat differently. Nicotinic acid is the starting material for the "Price-Handler Pathway". Here, NA is converted into NMN via the enzyme NAPRT.

Nicotinamide can also be converted to NMN as a precursor. Interestingly, the generated molecule can be converted back to NAD not only via the "de novo pathway" but also via the "salvage pathway", which is the most active of the three pathways. Thus, we can amplify all three pathways.

regeNAD - a power bundle with more than one approach

From human studies it can be deduced that administration of precursors alone is not always sufficient to increase NAD levels in the organism. Not only does the synthesis of NAD and recycling decrease, but degradation due to inflammation-induced CD38 increase. For this reason, we need more than one approach to increase NAD levels in your body.

According to the minimum law of the German chemist Justus von Liebig, growth is limited by the scarcest resource. Some of you still know the wine barrel with wooden slats of different heights. The lowest slat determines the height of the water level. It works similarly in our body. We need all resources in sufficient measure to be able to maintain the NAD metabolism. Here supports you regeNAD not only supports you with several precursors, it also offers you an additional trump card in the form of vitamin B6. Vitamin B6 is needed as a coenzyme for the conversion of NMN to NAD.

How can you actually measure the NAD level? Almost certainly not (yet) at your family doctor's office. Since this is not a routine measurement in the medical practice, we have developed an at-home test kit for your NAD level together with Vilnius University.

Learn where you stand and find out which method will help you maintain and increase your NAD levels.

NAD precursors: More material for your cells

regeNAD provides you with various precursors of NAD and the important co-factor vitamin B6. The amino acid L-tryptophan is the starting point of the "de novo synthesis" of NAD. The vitamin B3 derivatives nicotinic acid and nicotinamide can also be converted to NAD via various pathways. Thus, you are not only activating the "de novo pathway," but also the "price-handler pathway" and the "salvage pathway."

But that's not all that's in regeNAD.

A nice side effect of vitamin B3 in studies: the ApoB level decreases and HDL is increased. This gives you the chance to support your vascular health at the same time.

Degradation inhibition: Less CD38 increases your NAD levels

A varied diet, rich in vegetables and pulses, is the basis for a healthy life. The importance of a plant-based diet has been scientifically confirmed time and time again. One of the main reasons for the health-promoting effects of this diet is the secondary plant substances it contains. For the NAD metabolism these are apigenin and luteolin are of interest.

Apigenin

Apigenin belongs to the family of flavonoids and occurs naturally in plants such as parsley and camomile. In animal studies, the administration of apigenin was able to increase NAD levels by approx. 50%. The mechanism is the inhibition of CD38. The molecule also has strong anti-inflammatory and antioxidant effects. This effect is mediated by a reduction in inflammatory substances such as interleukin-6 (IL-6). It also supports various enzymes for glutathione metabolism and appears to have positive effects on vascular diseases and diabetes mellitus.

Luteolin

Another plant flavonoid is luteolin. It is found mainly in carrots, olive oil, thyme and rosemary. In high concentrations, luteolin has been shown to support the recycling of NAD (salvage pathway). This is the most important source of NAD in our body in terms of quantity. Luteolin acts by stimulating the key enzyme, NAMPT, which converts NAM to NMN. Key enzyme here means that the speed of the whole reaction depends on this enzyme. Thus, luteolin can boost NAD metabolism.

In addition to its role in NAD metabolism, luteolin affects other areas of our body. Similar to apigenin, luteolin has anti-oxidant and anti-inflammatory effects. Even more exciting for research is the interaction between luteolin and the "longevity genes", also called sirtuins. In addition to activation of SIRT1, some research groups are investigating the role of luteolin on SIRT6. Luteolin binds to SIRT6 and increases the activity of the enzyme twofold. This boosts DNA repair mechanisms, leading to healthier cells.

Did you know? Another molecule that can support inflammatory processes, glutathione metabolism and healthier mitochondria is GlyNAC. According to a large-scale human study by the Bayor College of Medicine, regular intake of GlyNAC led to a measurable strengthening of the mitochondria.

Green tea - an "insider tip" for NAD metabolism?

Last but not least, green tea also contributes a central ingredient of regeNAD - we are talking about epigallocatechin gallate (EGCG). Green tea has long been known in Asian culture for its health-promoting properties.

EGCG belongs to the group of catechins, a subgroup of the previously mentioned flavonoids. Catechins have a high antioxidant potential, which makes them very exciting molecules for research and science. Among others, the University of Saarland is conducting research on the medical use of EGCG. Some of the highly interesting results from studies on supplementation with EGCG are:

• In mice, the rise in blood glucose after a high-carbohydrate meal was reduced by half
• EGCG appears to have a protective effect for neurodegenerative diseases such as Alzheimer's and Parkinson's disease. The formation of the disease-causing amyloid fibrils was inhibited by EGCG in cell studies.
• Lowering the cholesterol level
• EGCG reduces age-related damage to the genetic material

EGCG has another property that makes it relevant for NAD metabolism. Namely, it stimulates the key enzyme NMNAT, which enables the very last step in NAD production. Since the activity of this enzyme decreases with age, EGCG is one way to support the enzyme.

regeNAD - Summary

It can be deduced from the many studies that higher NAD levels in old age are responsible for a variety of positive effects. Increased vitality, better memory performance, protective effects on metabolic diseases and age-related neurological disorders - the list of systems involved is long.

Precisely because of its universal role in the body, NAD metabolism is one of the most promising approaches in longevity research. With regeNAD we have formulated an innovative complex designed to maintain NAD levels not only through precursors, but also through enzyme induction and degradation inhibitors. In addition, you benefit from the versatile protective mechanisms of the secondary plant compounds apigenin, luteolin and EGCG.